STUDY OF THE CAUSES OF PARATHYROID HORMONE IMBALANCE AND SOME BIOCHEMICAL PARAMETER IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Abstract

         Parathyroid hormone (PTH) is produced and secreted by the parathyroid glands and acts on the kidneys and bones. It's the main factor regulating the homeostasis of serum calcium and phosphate levels. In this study, we evaluated several biochemical indicators of kidney function in patients with chronic kidney disease and mineral disorders. We tested the level of total calcium, phosphorus, parathyroid hormones, and vitamin D3. In patients with chronic kidney disease and treated by regular hemodialysis. The sample collation was performed at the Medical City Dialysis Center and Iraqi Dialysis Center in Medical City from October 2022 until April 2023. The study showed that the level of PTH, vitamin D3, Ca and PO4 was highly significant ((p ≤ 0.0001) increase in patients with Chronic Kidney Disease (CKD) in comparison with controls.

       There was a correlation between PTH levels and each (calcium, phosphor and vitamin D3) in CKD patient groups. This study showed that the increase in PTH levels leads to a decrease in total calcium levels and an increase in phosphor levels in patients with chronic kidney disease.

Keywords:  Parathyroid hormones, Vitamin D3, Calcium, Phosphor, Chronic kidney disease