EVALUATION OF ADROPIN AND ITS RELATIONSHIP WITH METABOLIC DISORDERS IN POLYCYSTIC OVARY SYNDROME

Abstract

Background: Adropin is a hormone that has been connected with several inflammatory disorders and has also been linked to metabolic problems that constitute a fundamental component of polycystic ovarian syndrome (PCOS).

Aim: The objective of the current study was to assess the level of adropin in patients with polycystic ovarian syndrome (POS) in Mosul City and investigate the correlation between adropin and indicators of metabolic.

Study Design: A case-control study.

Methods: 110 women between the ages of 15 and 45 were split into two groups: 47 women with regular menstrual cycles, who were classified as non-PCOS (apparently healthy), and 63 women classified as PCOS (based on Rotterdam criteria). PCOS was diagnosed in patients attending Al-Batoul Teaching Hospital (Obstetrics and Gynecology) in Mosul City, Iraq, who presented with oligomenorrhea (irregular menstrual periods), hyperandrogenism, and polycystic ovaries (on the ultrasound).

Ten milliliters of venous blood were extracted from the women fasting all night.  Clinical analyses were performed using the following methods: ELISA was used to measure the serum adropin level, metabolic factors which are fasting glucose, insulin, lipid profile, and standard formulas were used to calculate the IR indices (HOMA), (HOMA-%β), (HOMA-%S) and (TyG) were also estimated.

Results: it showed that adropin hormone levels were much lower in PCOS patients than in non-PCOS patients. Additionally, a significant increase in glucose, insulin, and the homeostasis model for insulin resistance (HOMA-IR), Triglyceride Glucose index (TyG), and lipid profile, also the results showed a decrease in the homeostasis model for β-cell function (HOMA-%β), the sensitivity of insulin (HOMA-%S) and there is a significant correlation between the adropin hormone with many indicators.

Conclusion: reduced levels of adropin were associated with Polycystic ovary syndrome and metabolic disorders. Therefore, it can be considered a new indicator and a promising tool for diagnosing initiating and developing Polycystic ovary syndrome.

Keywords: Adropin; polycystic ovary syndrome; Insulin resistance; Triglyceride Glucose index