ESTIMATION OF SALIVARY INTERLEUKIN 23 LEVELS IN HYPOTHYROIDISM AND HYPERTHYROIDISM PATIENTS

Authors

  • Riam Hassoun Harbi1; Maha Adel Mahmood1 Author

Abstract

Background: Interleukin 23 (IL-23) belongs to the interleukin 12 (IL-12) superfamily and is crucial for developing various autoimmune diseases. Previous study suggests that IL-23 have a vital function in the development of Hashimoto's thyroiditis (HT). This study aims to measure the concentrations of IL-23 in the patient’s saliva suffering from HT.

 

Materials and Methods: The case-control study was conducted on unstimulated saliva collected from 87 precipitate between 8 and 10 am in the early morning. Precipitate were divided in three groups as the following: hyperthyroidism, hypothyroidism, and healthy control group. Each group comprised 29 subject all of the participants aged between 30-60 years. The Sandwich enzyme linked immunosorbent assay (ELISA) was used for the detection and estimation of the level of IL23.

Results: Significant differences at P<0.01 accounted for the testing of the quality of variances concerning (IL-23) markers among studied groups, and no significant differences in testing the quality of means are assumed among the studied groups. Results show substantial differences at P<0.05 are accounted for between hyperthyroid patients and control groups concerning the IL-23 marker. IL-23 markers are too sensitive due to hyperthyroid patients. At the same time, weak sensitivity is presented with the leftover comparisons, such as between hypothyroid patients and control and between disease groups.

Conclusions: IL-23 has achieved excellent diagnosis in hyperthyroid patients under the guideline of a controlled group with a perfect sensitivity rate of diagnosis of the studied disease. In contrast, it did not achieve the marginal target level of diagnosis concerning hypothyroid patients.

Keywords: Thyroid disease, IL23, TSH, FT3. FT4

 

Downloads

Published

2024-03-19

How to Cite

ESTIMATION OF SALIVARY INTERLEUKIN 23 LEVELS IN HYPOTHYROIDISM AND HYPERTHYROIDISM PATIENTS. (2024). Romanian Journal of Diabetes, Nutrition and Metabolic Diseases, 31(1), 407-417. https://jrdiabet.ro/index.php/RJDNMD/article/view/310