IMMUNOLOGICAL ASPECT OF INF-γ, TNF-α AND ICAM-4 LEVELS IN A GROUP OF PATIENTS WITH GIT TUMOR IN BABYLON PROVENCE

Abstract

The study was planned to assessment the mean factors and risk population in which that exposure to infected with different GIT tumors, and determined the mean of population related to malignant GIT tumor than other tumor types. Measurement of certain immunological parameters are done to assessment it activity on such conditions. Serum samples were taken from  88 person they choose  to evaluating the level of different studied parameters and grouped as (Malignant GIT tumor (42) ,  Benign  GIT tumor (29) ,  Irritable bowel disease as a positive control (10)  and Health individual as a  negative control  (7) in related age group. All patients admitted in GIT and level center of Babylon in Marjan Medical city at April   up to December - 2020. The ICAM-4, INF-γ and TNF-a level were measured by using ELISA manual procedure of Elabscience company, Statistical analysis were done by using SPSS program.

The result show  younger male is more infected with malignant GIT tumor, than Benign GIT tumor as well as IBD and healthy individuals, and there is an   increased in ICAM-4 level , IFN- γ, in comparison with decreased of TNF-α levels. In the correlation study of  parameters revealed that the , level gradually decreased with age prognosis, increased ICAM-4 lead to decreased in IFN- γ and TNF- α level among patients infected with GIT tumor . While increased interferon might be lead to increase in ICAM-4 level.

In Conclusions : The early age male infected with malignant GIT tumor in Iraqi population. Serum ICAM-4 levels were higher in malignant patients compared to healthy controls and benign GIT tumors. Also, serum IFN-γ and TNF- α levels in malignant patients were higher than in benign GIT tumors. Specific more studies with large number of patients should be recommended to exclude the factors in which that lead to such conditions.