ESTIMATION OF BLOOD, SERUM AND TISSUE PARAMETERS OF Solanum torvum EXTRACT IN FEMALE ALBINO RATS.

Abstract

Solanum torvum a important medicinal plant have various pharmacological properties and found throughout India. The antifertility activity of the ethanolic extract of Solanum torvum (STE) was seen earlier and the haematological parameters post treatment in rats was not altered. The biochemical parameters in STE treated rats showed albumin, creatinine, GGT, LDH, SGOT, SGPT, urea, uric acid, total bilirubin and total protein were not altered. The cholesterol level was high and the result was found statistically significant by compared to control group animals. The female hormone levels were altered significantly the thyroid hormone levels was not altered. The tissue biochemical parameters like cholesterol, estrogen and progesterone level are altered and there was reduction in the weights of reproductive organs. Results of tissue biochemical parameters study in the reproductive organ of STE treated rats altered the protein, glycogen, sialic acid, cholesterol, ascorbic acid, acid phosphatase and alkaline phosphatase. In conclusion the STE treated female rats indicate adverse effect on uterine milieu, making it unsuitable for implantation.

Key Words: Solanum torvum, biochemical parameters, hormone and tissue biochemical parameters.