PLATELET SIZE IN DIABETES: A COMPREHENSIVE ANALYSIS OF MEAN PLATELET VOLUME IN MICROVASCULAR COMPLICATIONS OF DIABETES

Abstract

Introduction: Diabetes mellitus (DM) poses a global health challenge, with associated vascular complications contributing to morbidity and mortality. Mean platelet volume (MPV) has emerged as a marker of platelet activity, reflecting increased reactivity and thrombotic risk. This study investigates the relationship between MPV and microvascular complications in diabetes

Materials and methods: A case-control study involving 330 patients, including 165 with diabetic retinopathy (cases) and 165 without (controls), was conducted at Saveetha Medical College. Patients' MPV and HbA1c levels were measured, and statistical analysis was performed using IBM SPSS Statistics

Observation and results: The majority of patients were aged 41-60 and predominantly male. Significant differences in MPV and HbA1c were observed between the case and control groups (p < 0.01). The case group exhibited a significantly higher mean MPV compared to controls (12.75 vs. 10.67, p = 0.0005), indicating a potential biomarker for microvascular complications in diabetes.

Conclusion: Increased MPV serves as a predictive marker for microvascular complications in diabetes, facilitating early diagnosis and risk assessment. Utilizing MPV in clinical practice could enhance the management and prevention of diabetic vascular issues.

Keywords:  Mean Platelet Volume (MPV), Diabetic Retinopathy, Diabetes Mellitus, Microvascular complications of Diabetes.