A CASE REPORT OF POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME FOLLOWING RITUXIMAB THERAPY

Abstract

Posterior reversible encephalopathy syndrome (PRES) is a rare clinical disorder that is manifested by headache, confusion or altered consciousness, visual changes, and seizures, along with characteristic neuroimaging findings involving posterior cerebral white matter. Early recognition and prompt treatment are cardinal to prevent permanent damage of the cerebrum in this otherwise reversible condition.

In this case, we report a 23-year-old female diagnosed with Stage 4 lupus nephritis who was started on rituximab, following which the patient developed visual disturbances, headaches, and seizures. MRI brain revealed posterior reversible encephalopathy. Eventually, the patient made a full recovery after 2 months of hospital stay and was discharged.

Keywords: - Encephalopathy , lupus nephritis, rituximab.