THERAPEUTIC EFFICIENCY OF PROBIOTIC LACTOBACILLUS SPP. AGAINST OF CLOSTRIDIUM DIFFICILE-ASSOCIATED DIARRHEA

Abstract

Background: Antibiotic treatment can disturb the resistance of the gastrointestinal flora to colonization. This may result in complications, the most serious of which is Clostridium difficile associated diarrhea (CDAD). The study was to determine the effectiveness of probiotics for the prevention of CDAD. Clostridium Difficile is the most important cause of nosocomial diarrhea in adults. Illness may range from mild watery diarrhea to life-threatening colitis. Diagnosis is based primarily on the detection of C. difficile toxin A or toxin B. These toxins primarily disrupt the cytoskeletal structure and the tight junctions of target cells causing cell rounding and ultimately cell death. The toxins trigger a complex cascade of host cellular responses to cause diarrhea, inflammation and tissue necrosis- the major symptoms of CDI. Our findings indicate that probiotics may prevent CDAD. Most probiotics contain a singular strain. The combination with lactobacillus sp was the most effective at preventing CDAD. In addition, 6 out of 8 trials had an in relation to preventing CDAD containing Lactobacillus spp. Our findings indicate that probiotics may prevent CDAD. Most probiotics contain a singular strain. The combination with Lactobacillus spp. was the most effective at preventing CDAD. Conclusion: In addition, 6 out of 8 trials had an in relation to preventing CDAD containing lactobacillus sp. Four studies said that there were some factors that meant that the probiotic could not reduce or prevent the CDAD.

Keywords: CDAD, Toxin A, Toxin B, Gastrointestinal flora, Iraq